Consortium for Clinical Characterization of COVID-19 by EHR (4CE)

Principal Investigator: Isaac Kohane MD PhD (Harvard), Jason Moore PhD, Danielle Mowery PhD

Co-Investigators: John Holmes PhD, Jeffrey Morris PhD

Department: Institute for Biomedical Informatics

Description:
To better understand the disease burden, treatment efficacy, and patient outcomes associated with COVID-19 infection, a team of clinicians, epidemiologists, informaticists, statisticians, and data scientists from CTSA sites led by the i2b2 academic user group has formed. The objective is to leverage the i2b2 common data model to study COVID-19 EHR data from hospitals throughout the world.

• Klann, Jeffrey G.; Weber, Griffin M; Estiri, Hossein; Moal, Bertrand; Avillach, Paul; Hong, Chuan; Castro, Victor M; Maulhardt, Thomas; Tan, Amelia LM; Geva, Alon; Beaulieu-Jones, Brett K; Malovini, Alberto; South, Andrew M; Visweswaran, Shyam; Omenn, Gilbert S; Ngiam, Kee Yuan; Mandl, Kenneth D; Boeker, Martin; Olson, Karen L; Mowery, Danielle L; Morris, Michele; Follett, Robert W; Hanauer, David A; Bellazzi, Riccardo; Moore, Jason H; Will Loh, Ne Hooi; Bell, Douglas S; Wagholikar, Kavishwar; Chiovato, Luca; Tibollo, Valentina; Rieg, Siegbert; Li, Anthony LLJ; Jouhet, Vianney; Schriver, Emily; Samayamuthu, Malarkodi J; Xia, Zongqi; The Consortium for Clinical Characterization of COVID-19 by EHR (4CE); Kohane, Isaac S; Brat, Gabriel A; Murphy, Shawn N. Validation of a Derived International Patient Severity Phenotype to Support COVID-19 Analytics from Electronic Health Record Data. medRxiv. 10/2020. (Accepted to JAMIA)
• Brat GA, Weber GM, Gehlenborg N, Avillach P, Palmer NP, Chiovato L, Cimino J, Waitman LR, Omenn GS, Malovini A, Moore JH, Beaulieu-Jones BK, Tibollo V, Murphy SN, Yi SL, Keller MS, Bellazzi R, Hanauer DA, Serret-Larmande A, Gutierrez-Sacristan A, Holmes JJ, Bell DS, Mandl KD, Follett RW, Klann JG, Murad DA, Scudeller L, Bucalo M, Kirchoff K, Craig J, Obeid J, Jouhet V, Griffier R, Cossin S, Moal B, Patel LP, Bellasi A, Prokosch HU, Kraska D, Sliz P, Tan ALM, Ngiam KY, Zambelli A, Mowery DL, Schriver E, Devkota B, Bradford RL, Daniar M, Daniel C, Benoit V, Bey R, Paris N, Serre P, Orlova N, Dubiel J, Hilka M, Jannot AS, Breant S, Leblanc J, Griffon N, Burgun A, Bernaux M, Sandrin A, Salamanca E, Cormont S, Ganslandt T, Gradinger T, Champ J, Boeker M, Martel P, Esteve L, Gramfort A, Grisel O, Leprovost D, Moreau T, Varoquaux G, Vie JJ, Wassermann D, Mensch A, Caucheteux C, Haverkamp C, Lemaitre G, Bosari S, Krantz ID, South A, Cai T, Kohane IS. International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium. NPJ Digit Med. 2020 Aug 19;3:109. doi: 10.1038/s41746-020-00308-0. PMID: 32864472; PMCID: PMC7438496.