Risk of Persistent Opioid Use following Major Surgery in Matched Samples of Patients with and without Cancer | Penn Radiation Oncology/Psychiatry

Principal Investigators: Caryn Lerman PhD, Justin Bekelman MD

Department: Radiation Oncology, Psychiatry

Description (from journal abstract):
Persistent opioid use following curative intent surgery for cancer and factors influencing this risk are not well understood. We used electronic health record data from 3,901 adult patients who received a prescription for an opioid analgesic related to hysterectomy or large bowel surgery from January 1st, 2013 through June 30th, 2018. Patients with and without a cancer diagnosis were matched based on demographic, clinical, and procedural variables and compared for persistent opioid use.

Publications:

Falcone M, Luo C, Chen Y, Birtwell D, Cheatle M, Duan R, Gabriel PE, He L, Ko EM, Lenz HJ, Mirkovic N, Mowery DL, Ochroch EAA, Paulson ECC, Schriver E, Schnoll RA, Bekelman JE, Lerman C. Risk of persistent opioid use following major surgery in matched samples of patients with and without cancer. Cancer Epidemiol Biomarkers Prev. 2020 Aug 28:cebp.0628.2020. doi: 10.1158/1055-9965.EPI-20-0628. Epub ahead of print. PMID: 32859580.