Principal Investigator: Justin R. Harris, PharmD, BCPS
Department: Cardiology, Penn Medicine
Services Provided: Data Analysis
Publication: Anticipated summer journal submission
Description:
The optimal dose of warfarin varies among individuals, and the prediction of a maintenance dose is difficult. We will conduct a retrospective cohort study of 122 patients who underwent mechanical mitral valve surgery at PennMedicine. Approximately half of these patients received post-surgery warfarin treatment in the morning (10 am), while the other patients received warfarin in the evening (6 pm). We used a survival analysis approach to contrast the effect of administration time of warfarin on the time required to reach therapeutic INR level, adjusting for time-dependent (e.g.daily dose) and time-independent (e.g. sex, race) clinical features.
JR Harris, R Hatch, P Vallabhajosyula, Y Lo, D Mowery, N Patel. AM Versus PM Postoperative Administration of Warfarin With a Mechanical Mitral Valve. Journal of Pharmacy Technology, 1-6
